:Clear Skin Blog

While most megadose B5 users make the transition to time-release without any problems, I’ve noticed that some former megadose users have complained of needing more than our recommended dosage to stop acne, and sometimes still not getting as dramatic results. As far as I can tell, this could be due to two factors: Firstly, with people who have been megadosing for a while, their bodies may have adjusted to the abnormally high supply of vitamin B5, and simply not respond as well to the reduced dosage, even if it is more potent due to the time-release mechanism. Secondly (and this is the one I suspect is more true), most megadosers take their doses quite frequently throughout the day. Even with a time-release pill, the release of a vitamin is not perfectly constant, and may not have the same potency as more frequent intakes of a standard pill. This can be solved by taking the vitamin more frequently, but that somewhat diminishes the benefit of time-release (although you would still likely need less since it would be more efficiently absorbed).

I’m a former megadose B5 user myself, but my acne was already more or less gone by the time I started using time-release, so my body’s requirements were probably lower. For people who have not already been megadosing, I expect that time-release will be more readily effective (I certainly have a lot of customers who are seeing good results). We may be introducing a new smaller-size tablet in the near future, so that tablet will probably come with a recommended intake cycle of four times per day for best results. This may make the transition for previous megadosers easier.